Virulence Factor of Leptospira sp. Causes of Leptospirosis and Its Management

Conny Riana Tjampakasari; Wisiva Tofriska Paramaiswari

doi:10.55927/fjst.v4i3.36

Authors

Conny Riana Tjampakasari Department of Microbiology, Faculty of Medicine, Universitas Indonesia
Wisiva Tofriska Paramaiswari Magister Programme, Biomedical Science, Faculty of Medicine, Universitas Indonesia

DOI:

https://doi.org/10.55927/fjst.v4i3.36

Keywords:

Leptospirosis, Virulence Factor, Control

Abstract

Leptospirosis is often found in tropical and subtropical countries with high rainfall. Leptospirosis outbreaks have been reported throughout the world and in Indonesia is still a problem with the outbreak of several Extraordinary Events in various regions. This bacterium has several virulence factors, including Leptopsiral Microbial Surface Component Recognizing Adhesive Matrix Molecules (MSCRAMM), Lipopolisakarida (LPS), Loa22, LipL32 or hemolysis-associated protein I (Hap I), Protein Len/Protein Lsa24, Protein LigA (Leptospiral Immunoglobulin-Like Proteins) and HemO. The diagnosis of leptospirosis is made based on laboratory examination, but not all countries, especially developing countries, are able to carry out examinations for Leptospira sp., so many cases go unreported. By studying the role of virulence factors, it is hoped that the self-defense mechanisms of bacteria in the host can be identified so that they can increase the potential to prevent their pathogenicity from causing disease. Control of Leptospirosis consists of primary prevention, namely protection of healthy people from VOID Leptospirosis, promotive in nature, and specific protection by means of vaccination; secondary prevention targets people who are already with Leptospira, by preventing complications that can cause death. Efforts to control Leptospirosis must be implemented thoroughly so that outbreaks do not continue.

References

Antony VS, Tan CS , Karanam SB, Chamarthy SS, SaiPriya C, Raji P, Emilin RR, Suresh KS and Pooi LM. Leptospiral Infection, Pathogenesis and Its Diagnosis—A Review. Pathogens. 2021:10, 145. https://doi.org/10.3390/pathogens10020145

Asih R, Yos AP, Kurnia D. Correlation of Serology Test Result Against Leptospira Sp. to The Representation of Histopathological Lesions on The Cattle Kidney. Journal of Medical Laboratory Science Technology. Juli 2021:4(1);30-34

Barkah W, Agus I, Agustina H, Kasiyanto, Marleni, Purwaning R, Tri Wahyuningsih. Edukasi Untuk Meningkatkan Pengetahuan dan Kesadaran Masyarakat Dalam Pencegahan Leptospirosis. Jurnal Salingka Abdimas. Juni 2023: 3(1 ); 177-182

Davignon G, Cagliero J, Guentas L, Bierque E, Genthon P, Gunkel-Grillon P, Juillot F, Kainiu M, Laporte-Magoni C, Picardeau M, Selmaoui-Folcher N, Soupé-Gilbert M-E, Tramier C, Vilanova J, Wijesuriya K, Thibeaux R and Goarant C. Leptospirosis: toward a better understanding of the environmental lifestyle of Leptospira. Frontiers in Water. Juli 2023:5; 1195094.

Fragma AS, Munfika M, Karlina SS. Severe Leptospirosis. Cermin Dunia Kedokteran 298. 2021:48(11):353-356

Guntari TM, Sri H, Hastari W, Ida T, Yuriadi, Irkham W, Yanuartono, Hary P, S Indarjulianto, Slamet R, Alfariza N, Angeline G, Yeo SJ. Identification of Serovar that Caused Canine Leptospirosis in Yogyakarta. Jurnal Sain Veteriner. Desember 2019:37(2);227-231

Isnaini AZ, Dyah MS. Analisis Spasial Kasus Leptospirosis Berdasar Faktor Epidemiologi dan Faktor Risiko Lingkungan. Higeia Journal of Public Health Research and Development. 2020:4(4);587-598

Lester JP, Saraswathi L, Vanessa JD, Richard LF, Carol WM. A Validated Multiplex Real-Time PCR Assay for the Diagnosis of Infectious Leptospira spp. : A Bovel Assay for the Detection and Differentiation os Strains from Both Pathogenic Groups I and II. Forntiers in Microbiology. March 2020:11(457); 1-18

Muhammad FM , Mochammad H. Identifikasi DNA Leptospira sp Pada Sampel Air dan Tanah Di Kota Makassar. As-Syifaa. Juli 2018: 10 (01);7-43. ISSN : 2085-4714

Mujahidah, Maria EK, Desvita S , Subakir. Leptospirosis dengan Gangguan Ginjal : Laporan Kasus. Jambi Medical Journal. 2023: 11(1);117-122.

Muslimin B, Syifa MP, Putri MR, Ramdesima K, Dian W. Study Of Risk Factors And Leptospira Detection Of Sanitary Workers In Jakarta, Indonesia. Biomedika. Aguatus 2022:14(2); 118-126

Muslimin BS , Dian W, Karimulloh. Identification of Leptospira Bacteria in Human Urine According to Islamic View. International Islamic Medical Journal. December 2020:2(1);24-29

Noraini Philip1, Jaeyres Jani2, Nurul Natasya Azhari1,, Zamberi Sekawi1 and Vasantha Kumari Neela. In vivo and in silico Virulence Analysis of Leptospira Species Isolated From Environments and Rodents in Leptospirosis Outbreak Areas in Malaysia. Forntiers in Microbiology. March 2021:2(753328); 1-15

Novie HR. Leptospirosis. Jurnal Biomedik. November 2016:8(3);143-150

Rima T, Sechan A, Mohammad AA. Penerapan Metode Naïve Bayes Dalam Mendiagnosa Penyakit Leptospirosis. Journal of Computer System and Informatics. August 2022:3(4);521-526

Riyandini P, Susanti, Andi M. Efek Desinfektan Terhadap Leptospira Interrogans Serovar Hardjo. Prosiding Seminar Nasional Teknologi Dan Agribisnis Peternakan X: “Peningkatan Kapasitas Sumberdaya Peternakan Dan Kearifan Lokal Untuk Menghadapi Era Society 5.0” Fakultas Peternakan Universitas Jenderal Soedirman, 20 – 21 Juni 2023, Hal. 322-327

Senaka Rajapakse. Leptospirosis: clinical aspects. Clinical Medicine. 2022:22(1): 14–7

Syamsuar M, Hasnawati A, Sri IR. Identification of Leptospira Serovar in Leptospirosis Suspect Serum in Manggala Subdistrict, Makassar City. Open Access Maced Journal of Medical Sciences.May 2021:14 (9B):407-410.

Tri R, Diah W. Identifikasi Serovar Bakteri Leptospira Pada Tikus Kaitannya Dengan Kejadian Leptospirosis Di Beberapa Kabupaten Di Provinsi Jawa Tengah. Jurnal Pembangunan Manusia. Desember 2014: 8 (3):189-201

Widjayanti W. Epidemiologi, diagnosis, dan pencegahan Leptospirosis. JHECDs.2019: 5 (2) 2019, 62-68

Yolanda H, Evita M. Relationship between Knowledge and Attitude with Behavior of Preventing Leptospirosis in Healthcare Workers at Binjai City. Sumatera Medical Journal. 2022:5(1): 1 – 7