Epigenetic Resilience and Lifestyle Modulation as Predictors of Healthy Aging in Urban Population

Muhammad Syahrir; Besse Hardianti; Rudy Dwi Laksono

doi:10.55927/fjst.v4i12.344

Authors

Muhammad Syahrir Universitas Tompotika Luwuk
Besse Hardianti Universitas Almarisah Madani
Rudy Dwi Laksono Universitas Jenderal Ahmad Yani Cimahi

DOI:

https://doi.org/10.55927/fjst.v4i12.344

Keywords:

Epigenetic Resilience, Lifestyle Modulation, Healthy Aging, Urban Population

Abstract

This study investigates how epigenetic resilience and healthy lifestyle behaviors predict optimal aging in urban environments. Using a mixed-methods sequential explanatory design, data were collected from 48 adults aged 45–70 through lifestyle questionnaires, clinical assessments, and DNA methylation analysis to estimate epigenetic age, followed by in-depth interviews. Regression and mediation analyses show that active living, balanced nutrition, and effective stress management significantly enhance epigenetic resilience and slow biological aging. The findings highlight epigenetic resilience as a key adaptive mechanism linking healthy behaviors to improved aging outcomes. Practically, the study offers scientific support for developing preventive strategies and lifestyle-based urban policies aimed at strengthening biological resilience and extending the healthspan of urban populations.

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